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It's all a matter of personal preference. I'm personally comparing the (affiliate link) Osprey Porter 46 Travel Backpack vs (affiliate link) Eagle Creek Digi Hauler 44L Backpack.
There's only so much you can research online, so next step is getting myself to an Outdoor Adventure Travel store.
I didn't include the Tom Bihn Aeronaut 45L in the running. I'm a fan but with a whopping price of
$250.00 $300.00 (2020), it was just too much out of my price range... especially wanting to invest into accessories such as: (affiliate link) Eagle Creek Pack-It Specter Cube Set (XS, S, M).